Garrett <i>et. al. </i>(2023). Isolated cardiac muscle contracting against a real-time model of systemic and pulmonary cardiovascular loads - Supplementary Figures.

<p dir="ltr">Supplementary figures for Garrett et. al (2023) Isolated cardiac muscle contracting against a real-time model of systemic and pulmonary cardiovascular loads. Accepted for Publication in American Journal of Physiology - Heart and Circ (as of 11th September 2023). </p><p dir="ltr">Figure S1: Normalized isometric force twitch used as the driver of the model that serves as the activation function (e(t)) in simulating the systemic-pulmonary hemodynamic model. This force twitch was measured from an isolated rat cardiac trabecula contracting in vitro (Taberner et al., 2011).</p><p dir="ltr">Figure S2: Pressures (A) and flow rates (B) of the left ventricle computed from simulation of the six-compartment systemic-pulmonary model.</p><p dir="ltr">Figure S3: Simulated PV loops for the six-compartment systemic-pulmonary model. Panel A displays PV loops with systemic resistance (<i>R</i>_<em>SYS</em>) values of 115 GPa·s·m^-3 (dashed) and 175 GPa·s·m^-3 (solid) used to tune the model, coinciding with muscle length change from 0.95 <i>L</i>_<em>o</em> to <i>L</i>_<em>o</em>. Panel B displays PV loops for <i>R</i>_<em>SYS</em> values ranging from low (50 GPa·s·m^-3) to high (500 GPa·s·m^-3), as indicated by the arrow.</p>