Garrett et. al. (2023). Isolated cardiac muscle contracting against a real-time model of systemic and pulmonary cardiovascular loads - Supplementary Figures.
Supplementary figures for Garrett et. al (2023) Isolated cardiac muscle contracting against a real-time model of systemic and pulmonary cardiovascular loads. Accepted for Publication in American Journal of Physiology - Heart and Circ (as of 11th September 2023).
Figure S1: Normalized isometric force twitch used as the driver of the model that serves as the activation function (e(t)) in simulating the systemic-pulmonary hemodynamic model. This force twitch was measured from an isolated rat cardiac trabecula contracting in vitro (Taberner et al., 2011).
Figure S2: Pressures (A) and flow rates (B) of the left ventricle computed from simulation of the six-compartment systemic-pulmonary model.
Figure S3: Simulated PV loops for the six-compartment systemic-pulmonary model. Panel A displays PV loops with systemic resistance (RSYS) values of 115 GPa·s·m-3 (dashed) and 175 GPa·s·m-3 (solid) used to tune the model, coinciding with muscle length change from 0.95 Lo to Lo. Panel B displays PV loops for RSYS values ranging from low (50 GPa·s·m-3) to high (500 GPa·s·m-3), as indicated by the arrow.