CellML, PMR, and the Physiome journal

<p dir="ltr">Invited plenary presented at COMBINE 2025, October 20-23, Madison, WI, USA.</p><p dir="ltr"><b>Abstract:</b></p><p dir="ltr">In this presentation I will provide a status report on CellML, the Physiome Model Repository (PMR), and the Physiome journal (https://journal.physiomeproject.org). Our recent efforts with CellML have focused on improving the usability for developers and modellers and attempts at improving the semantic annotation of models. libCellML is now readily available for programmatic access to CellML models and the new OpenCOR provides an entirely browser-based model simulation environment. I'll briefly touch on how we are using this browser technology on the SPARC Portal (https://sparc.science). To improve model discovery and reuse, enriching CellML models with semantic metadata is essential. I'll present some recent progress toward automating annotation of existing models. PMR is close to launching a completely rebuilt technology stack. I'll present the current repository and our plans for the new PMR. The Physiome journal was launched at the 2017 IUPS congress with the mission to improve the reproducibility of computational models of physiology in the published literature. This was to be achieved by providing a platform for a "secondary" publication, in association with a traditional primary publication, in which the authors could provide the implementation and instructions required to reproduce the results presented in the primary article. Here I will present the current status of the journal and evaluate how far we have come since the 2017 launch in achieving our mission. We will discuss the lessons learned along the way and the current challenges we are facing and our plans to address them.</p>