The human voice is a marvel of complexity that undergoes several landmark changes throughout a lifetime. A once experienced and confident voice user can become anxious when they find their voice is no longer ‘what it used to be’. Physiological changes in the voice mechanism lead not only to changes in the acoustic presentation of the voice, but also in the physical sensations that accompany phonation. This lecture will highlight some key developments in the human voice across a lifetime and will offer suggestions as to how to maintain healthy, efficient, and enjoyable voice use despite the inevitable challenges of age-related body changes.