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Shree Vijayaswathi Senthil Kumar: Calcium Signalling: A novel platform for screening anti-obesity therapeutics

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Obesity, a global epidemic, has no effective treatment. It takes several years to develop and assess drugs targeted to melanocortin-4-receptor in the brain, a key regulator of obesity. The distinct calcium response between obesity-causing/protecting melanocortin-4-receptor variants serve as a rapid screen to narrow down drug of interest for further investigation.

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