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Phoebe Burns: Investigating the influence of hypoxia on cGAS-STING signalling in macrophages

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posted on 30.09.2021, 06:06 by Phoebe Burns
Macrophages are immune cells often found in the oxygen-starved (hypoxic) regions of solid tumours. We investigated the effect of hypoxia on the anti-tumour interferon response in macrophage models. We found that hypoxia suppressed interferon signalling, decreased secretion of pro-inflammatory mediators, and promoted the acquisition of immunosuppressive changes in macrophage models.

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