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Copy of Phoebe Burns Poster - Investigating the influence of hypoxia on cGAS-STING signalling in macrophages.tiff (2.36 MB)

Phoebe Burns: Investigating the influence of hypoxia on cGAS-STING signalling in macrophages

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posted on 2021-09-30, 06:06 authored by Phoebe Burns
Macrophages are immune cells often found in the oxygen-starved (hypoxic) regions of solid tumours. We investigated the effect of hypoxia on the anti-tumour interferon response in macrophage models. We found that hypoxia suppressed interferon signalling, decreased secretion of pro-inflammatory mediators, and promoted the acquisition of immunosuppressive changes in macrophage models.

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