Phoebe Burns: Investigating the influence of hypoxia on cGAS-STING signalling in macrophages

Macrophages are immune cells often found in the oxygen-starved (hypoxic) regions of solid tumours. We investigated the effect of hypoxia on the anti-tumour interferon response in macrophage models. We found that hypoxia suppressed interferon signalling, decreased secretion of pro-inflammatory mediators, and promoted the acquisition of immunosuppressive changes in macrophage models. Choose your favourite poster to win the People's Choice Award at the 2021 SGS Research Showcase: https://auckland.au1.qualtrics.com/jfe/form/SV_9Fw8Omf43pstYUu