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Prolonged transitional neonatal hypoglycaemia: characterisation of a clinical syndrome

journal contribution
posted on 2020-12-07, 00:33 authored by Mirdanda J Bailey, Allie Rout, Jane E. Harding, Jane Marie Alsweiler, Wayne S. Cutfield, Chris MckinlayChris Mckinlay
Background: We performed a case-control study to characterise infants with “prolonged transitional hypoglycaemia”. Methods: Cases were born ≥36 weeks’ gestation; had ≥1 hypoglycaemic episode <72h and ≥72h; received ongoing treatment for hypoglycaemia ≥72h; and were without congenital disorders or acute illness. Cases were compared to controls born ≥36 weeks’ with brief transitional hypoglycaemia, resolving <72h. Results: 39/471 infants screened met case definition: 71.8% were male, 61.5% were small-for-gestational-age (SGA), and most were admitted <6h. Compared to controls (N=75), key risk factors for prolonged transitional hypoglycaemia were SGA (OR=6.4, 95%CI 2.7–15.1), severe/recurrent hypoglycaemia <24h (OR=16.7, 95%CI 4.5–16.1), intravenous glucose bolus <24h (OR=26.6, 95%CI 9.4–75.1) and maximum glucose delivery rate <48h of ≥8mg/kg/min (OR=25.5, 95%CI 7.7–84.1). Conclusions: Infants with prolonged transitional hypoglycaemia are predominantly male, SGA and have early severe/ recurrent hypoglycaemia requiring glucose boluses and high glucose delivery rates in the first 24–48h.

Published in Journal of Perinatology 2020

Published data are available to approved researchers under the data sharing arrangements provided by the Clinical Data Research Hub (CCRH), based at the Liggins Institute, University of Auckland. Contact



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