<p dir="ltr">Supplementary Data 1. STRING protein-protein interaction network in lung.</p><p dir="ltr">Supplementary Data 2. PROPER protein-protein interaction network in lung.</p><p dir="ltr">Supplementary Data 3. STRING protein-protein interaction network in whole blood.</p><p dir="ltr">Supplementary Data 4. PROPER protein-protein interaction network in whole blood.</p><p dir="ltr">Supplementary Data 5. Genes causal for asthma in the lung GRN identified using Mendelian randomisation (Wald ratio method).</p><p dir="ltr">Supplementary Data 6. Genes causal for asthma in the Blood GRN identified using Mendelian randomisation (Wald ratio method and inverse variance weighted).</p><p dir="ltr">Supplementary Data 7. significantly enriched (hypergeometric test, FDR≤0.05 and 500 sets of Monte Carlo simulations) asthma-trait interactions.</p><p dir="ltr">Supplementary Data 8. curated gene-disease associations from DisGeNet for the identified level 0-4 genes (hypergeometric test, FDR≤0.05).</p><p dir="ltr">Supplementary Data 9. Comorbidity analysis using health records of 2051661 hospitalized patients, 26781 of which had asthma (ICD10-AM code J459).</p><p dir="ltr">Supplementary Data 10. list of level 0-4 genes (hypergeometric test, FDR≤0.05 and 500 sets of Monte Carlo simulation) that are part of the druggable genome and/or have known drug targets and/or have been causally associated with asthma through Mendelian Randomization.</p>