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asthma_comorbidities_suppl_data_1.xlsx (116.3 kB)

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10 files

Zaied et al. supplementary data 1 - 10

dataset

posted on 2023-12-28, 01:32 authored by Roan ZaiedRoan Zaied

Supplementary Data 1. STRING protein-protein interaction network in lung.

Supplementary Data 2. PROPER protein-protein interaction network in lung.

Supplementary Data 3. STRING protein-protein interaction network in whole blood.

Supplementary Data 4. PROPER protein-protein interaction network in whole blood.

Supplementary Data 5. Genes causal for asthma in the lung GRN identified using Mendelian randomisation (Wald ratio method).

Supplementary Data 6. Genes causal for asthma in the Blood GRN identified using Mendelian randomisation (Wald ratio method and inverse variance weighted).

Supplementary Data 7. significantly enriched (hypergeometric test, FDR≤0.05 and 500 sets of Monte Carlo simulations) asthma-trait interactions.

Supplementary Data 8. curated gene-disease associations from DisGeNet for the identified level 0-4 genes (hypergeometric test, FDR≤0.05).

Supplementary Data 9. Comorbidity analysis using health records of 2051661 hospitalized patients, 26781 of which had asthma (ICD10-AM code J459).

Supplementary Data 10. list of level 0-4 genes (hypergeometric test, FDR≤0.05 and 500 sets of Monte Carlo simulation) that are part of the druggable genome and/or have known drug targets and/or have been causally associated with asthma through Mendelian Randomization.