blood_grn_sig_interactions.txt.gz (75.07 MB)
Whole blood spatial gene regulatory network
datasetposted on 18.01.2022, 10:55 authored by Roan ZaiedRoan Zaied, Tayaza FadasonTayaza Fadason, Justin O'SullivanJustin O'Sullivan
This dataset consists of spatially constrained eQTLs. Briefly, all common single nucleotide polymorphisms (SNPs; MAF >0.05) present in whole blood were obtained from GTEx v8 and used to interrogate prepared Hi-C libraries. This allowed for the identification of SNP-gene pairs that are physically interacting. The identified SNP-gene pairs were then tested for eQTL effects by integrating eQTL data from GTEx v8. eQTLs with an adjusted p-value ≤0.05 were selected as being significant (Benjamini-Hochberg).