Supplementary data 1. Significant eQTL-gene contacts identified within LGRN, Ensembl gene annotations, and LOEUF analysis results

The liver gene regulatory network (LGRN) we constructed consisted of 327,145 eQTLs and 8097 genes with 468,560 distinct spatially constrained eQTL-target gene interactions. The majority of the eQTLs (92% with single target genes, and 95% with multiple target genes) acted via cis regulatory interactions. Within the LGRN, 77% of the eQTL target genes are protein coding. Moreover, the genes that were targeted by trans-eQTLs are more likely to be intolerant to loss-of-function mutations.