eQTLs in the poly-unsaturated fat metabolism cluster
datasetposted on 2018-11-07, 13:51 authored by Tayaza FadasonTayaza Fadason, William SchierdingWilliam Schierding, Thomas LumleyThomas Lumley, Justin O'SullivanJustin O'Sullivan
Chromatin interactions (using Hi-C) and functional (using eQTL) data were used to identify long-range regulatory associations involving >20,000 GWAS variants and their target genes (i.e. eGenes). Convex biclustering was then used to segregate phenotypes that share eGenes, which implies a common underlying molecular mechanism. In the cluster that is built around the FADS locus, SNPs have inverse eQTL effects on FADS1, FADS2, and the other genes in the region. Here, the reference and alternate alleles of the SNP positions are given with their frequencies.