The University of Auckland
Browse
1/1
2 files

HVN PANaMAH RUTIN Metadata Record - Effect of rutin on insulin secretion in prediabetes

dataset
posted on 2024-05-16, 04:44 authored by Sally PoppittSally Poppitt

This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future.

Description: This trial investigated the efficacy of 500 mg rutin, in a double blind randomised 3-arm placebo controlled parallel study over 6 months in male and female participants with demonstrated prediabetes (fasting plasma glucose: = 5.6-6.9mmol/L). Each participant consumed once daily either: yogurt control + capsule control OR yogurt with 500 mg rutin + capsule control OR capsule 500 mg rutin + yogurt control, as part of their breakfast meal or as a later snack.

History

Publisher

University of Auckland

Temporal coverage: start

2018-01-01

Temporal coverage: end

2019-01-01

HVN Project / Programme Name

HVN PANaMAH RUTIN

Data access requirements

No individual participant data will be made available for this trial.

Principal investigator organisation

University of Auckland

Collaborating researchers and affiliations

Principal Investigators: Professor Sally Poppitt, Director, Human Nutrition Unit, University of Auckland, Auckland Dr Ivana Sequiera-Bisson, Human Nutrition Unit, University of Auckland, Auckland Associate Investigators: Dr Rinki Murphy (University of Auckland) Dr Mike Taylor (University of Auckland)

Data description

Outcomes of the study and associated data Primary outcome - Pancreatic β cell insulin secretion assessed as incremental area under the concentration-time (AUC) curve for C-peptide and glucose Associated data: c-peptide/glucose ratio as indirect marker of Pancreatic β cell insulin secretion, fasting and postprandial plasma glucose, insulin and C-peptide Secondary outcomes - Biochemistry panel, full lipid profile, inflammatory cytokines and associated obesity-related biomarkers - Plasma rutin Associated data: HbA1c, cholesterol (total-C, LDL-C, HDL-C), triglyceride, liver function enzymes (AST, ALT, ALP, GGT), plasma rutin Other outcome measures and associated data - Gut microbiome - Height - Weight - Waist and hip circumference - Body composition - total fat and lean mass, measured by dual energy x-ray absorptiometry (DXA) - Blood pressure - Adverse events - Dietary compliance via 4-day food records

Principal investigator contact email

s.poppitt@auckland.ac.nz

Usage metrics

    High Value Nutrition, Ko Ngā Kai Whai Painga

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC