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Description: The MultiProMo trial is a nutritional study to evaluate the influence of food digestibility on amino acid metabolism in healthy men aged 50-70. On each trial day, fasted participants consume one of three high-protein drinks and provide blood and urine samples over 5 hours. This is a cross-over study, so each participant consumes all three drinks on separate days. Levels of amino acids and digestion-related metabolic compounds are measured in blood and urine, in order to understand the release and supply of nutrients for support skeletal muscle synthesis and maintenance. Participants rate satiety and thirst in the period after drink consumption.
Publisher
University of AucklandTemporal coverage: start
2016-01-01Temporal coverage: end
2019-01-01HVN Project / Programme Name
MultiProMoData access requirements
Individual participant data will be unavailablePrincipal investigator organisation
Riddet Institute (Massey University)Collaborating researchers and affiliations
Principle Investigator
Distprof Harjinder Singh, Director, Riddet Institute, Massey University
Associate Investigators
Dr Simon Loveday (Riddet Institute, Massey University)
Dr Teresa Wegrzyn (Ridette Institute, Massey University)
Dr Sharon Henare (Massey University)Data description
Outcomes of the Study and associated data
Primary Outcome:
Identification of the kinetics of amino acid release on digestion during the 5 hours post-ingestion, based on the concentration of plasma amino acids in peripheral blood as a comparison to the comparator whey protein drink.
Associated data: Plasma amino acid profile
Secondary Outcomes:
-Identification of differences in metabolite profile of urine metabolites between the three trial drinks
-Determine and compare the satiating effect of the three drinks
-Determine and compare the effect on thirst rating of the three drinks
Associated data: Urine metabolite profile (NMR spectroscopy data), Visual Analogue Scale Questionnaire (Satiety), Visual Analogue Scale Questionnaire (Thirst)Principal investigator contact email
h.singh@massey.ac.nz