HVN Los aMiGos Metadata Record - Is LactOSe tolerance impacted by repeated exposure to A2 beta-casein MIlk, with effects on Gut COmfort Symptoms

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Description: Many people report digestive problems with dairy products. This dairy intolerance may sometimes be caused by lactose intolerance, but not all people reporting intolerance have confirmed lactose intolerance. Rather, some forms of dairy intolerance may be caused or exacerbated by the protein in milk which manifests as inflammation of the small intestine. Conventional milk contains the A1 version of bovine beta-casein protein. A1 beta-casein may cause intolerance type symptoms in some consumers, resulting in small intestinal inflammation that may also contribute to lactose intolerance. It is proposed that these effects are absent or reduced when dairy products free of this variant are consumed. The A2 version of beta-casein is broken down differently, and may not cause intolerance symptoms in consumers who are sensitive to the A1 beta-casein protein. However, the impacts of variation in beta-casein and intestinal inflammation on lactose malabsorption have not yet been investigated in humans. Due to the possible exacerbation of lactose malabsorption by intestinal inflammation, this study aims to understand whether tolerance to lactose is impacted by repeated exposure to variants of beta-casein.