This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future.
Description: This cross-sectional observational case-control study was initiated in July 2016 with the aim of increasing an understanding of the underlying disease mechanisms in functional gastrointestinal disorders (FGIDs) including irritable bowel syndrome (IBS), functional diarrhoea (FD), and functional constipation (FC). Specific areas of interest include the effect of food, microbiome, host and microbial genetics, metabolome, and psychological variables on unexplained chronic gastrointestinal (GI) symptoms.
Demographic, symptom, psychological, dietary, and health data were collected from 349 enrolled participants in addition to biological samples (breath, faeces, blood and urine). Colonic biopsies were taken at the time of colonoscopy from participants in the colonoscopy subgroup (n=220).
Publisher
University of AucklandTemporal coverage: start
2016-01-01Temporal coverage: end
2018-01-01HVN Project / Programme Name
HVN COMFORTData access requirements
Individual data is not available for the public due to ethical restrictions and required packages needed to view raw data.Principal investigator organisation
University of Otago, ChristchurchCollaborating researchers and affiliations
Principal Investigators:
Richard Gearry, Department of Medicine, University of Otago, Christchurch
Simone Bayer, Department of Medicine, University of Otago, Christchurch
Associate Investigators:
Phoebe Heenan (University of Otago)
Nicole Roy (University of Otago)
Rob Creemers (University of Otago)
Shriya Sharma (University of Otago)
Jacqueline Keenan (University of Otago)
Wayne Young (AgResearch)
Janine Cooney (Plant and Food Research)
Kelly Armstrong (AgResearch)
Karl Fraser (AgResearch)
Paul Skidmore (University of Otago)
Nicholas Talley (Plant and Food Research)
COMFORT Cohort CollaboratorsData description
Outcomes of the study and associated data
Primary outcome
- Case identification and description of cohort
Associated data: ROME IV, SF12, medical history, HADS, demographics
Secondary outcomes
- Structured Assessment of Gastrointestinal Symptoms (SAGIS) Questionnaire
- Economic Living Standard Index short form (ELSI-sf)
- Modified Patient Reported Outcomes Measurement Information System (PROMIS) Questionnaires
- Food and Symptom Times (FAST) Questionnaire
- Faecal/stool samples
- Urine samples
- Blood samples
- Breath samples
- Colonic mucosa samples
Associated data: SAGIS, ELSI-sf, PROMIS, FAST, faecal targeted metabolomics, faecal untargeted metabolomics, faecal metagenomics and 16S DNA-Seq, urine metabolomics, blood metabolomics, plasma neuromarkers, peripheral blood mononuclear cells (PBMCs), plasma immune markers, DNA samples, breath metabolomics, colonic mucosa samples,
Other outcomes and associated data: Anthropometry (BMI, height, weight) ,PBMC DNA sequences, PBMC genotyping data, Plasma stress hormones, colonic histology cell counts (goblet cells, eosinphiles, intra-epthithelial lymphocytes), Barrier function RNA dataPrincipal investigator contact email
richard.gearry@otago.ac.nz
