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HVN 1912 Metadata Record - Researching the role of Greenshell mussels and selected lifestyle and nutritional factors in participants with early signs and symptoms of knee osteoarthritis (The ROAM Study)

dataset
posted on 2024-04-10, 04:46 authored by Marlena Kruger, Pamela von Hurst

This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future.

Description: To evaluate the joint­-sparing effects of 26 weeks of daily intake of flash­dried powder from whole Greenshell mussel meat (3 gram per day), in older (60-74yrs) healthy adults with early signs or symptoms of osteoarthritis. This will be achieved by monitoring changes in cartilage markers of degradation and synthesis: including type II procollagen (CP­II), C­-telopeptide of type II collagen (CTX­II) and cartilage oligomeric matrix protein (COMP); changes in inflammatory markers: including cytokines IL-1a, IL-1ß, IL-18 and TNF-a; changes in patient reported outcome measures (PROMs): including the Knee Injury and Osteoarthritis Score (KOOS), Measure of Intermittent and Constant Pain (ICOAP) and Visual Analog Scale for Pain (VAS) and lastly changes in performance outcome measures measured by the OARSI physical function assessment tests: 30 second chair stand test, stair climb test and 40m fast paced walk test.

The secondary objective is to look at the association between the inflammatory potential of the diet, inflammatory and cartilage biomarkers, PROMS and performance outcome measures for those with early signs and symptoms of osteoarthritis.

History

Publisher

University of Auckland

Temporal coverage: start

2020-01-01

Temporal coverage: end

2022-01-01

HVN Project / Programme Name

HVN1912

Data access requirements

Individual participant data will not be made available

Principal investigator organisation

Massey University

Collaborating researchers and affiliations

Primary Investigators: Professor Marlena Kruger, College of Health, Massey University (Manuwatu Campus) Associate Professor Pamela Von Hurst, School of Sport and Exercise and Nutrition, Massey University (Albany Campus) Associate Investigators: Dr Matt Miller (Cawthron Institute) Dr Kathryn Beck (Massey University) Dr Cath Conlon (Massey University)

Data description

Outcomes of the Study and associated data Primary outcomes -Changes in cartilage synthesis and degradation biomarkers measured at baseline and the end of the intervention -Changes in patient reported outcome measures at baseline and the end of the intervention Associated data: Serum type II procollagen (CP­II) level, serum c-­telopeptide of type II collagen (CTX­II) level, serum cartilage oligomeric matrix protein (COMP) level, Knee Injury and Osteoarthritis Outcome Score (KOOS) Questionnaire, measure of Intermittent and Constant Pain (ICOAP) Questionnare, Visual Analog Scale for Pain (VAS), Composite assessments of physical function (30 second chair stand test, stair climb test and 40m fast paced walk test) Secondary outcomes -Inflammatory potential of the diet measured at baseline and end of the intervention - Inflammatory markers measured at baseline and end of the intervention Associated data: Dietary inflammatory index (DII), Serum inflammatory markers (cytokines including IL-1a, IL-1ß, IL-18 and TNF-a)

Principal investigator contact email

m.c.kruger@massey.ac.nz