The University of Auckland
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HVN1943 Metadata Record - Effects of collagen hydrolysate and milk protein on joint comfort and skin appearance in women over 50.

posted on 2024-04-10, 04:37 authored by Jane Coad

This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future.

Description: Previous research suggests consumption of hydrolysed collagen preparations may alleviate symptoms of osteoarthritis, the most common type of arthritis, usually affecting the knee, and with limited options for treatment. Inflammation and concomitant destruction of collagen in the connective tissue extracellular matrix are common mechanisms in osteoarthritis. Furthermore, most global collagen supplements are marketed as anti-ageing nutricosmetics to enhance skin appearance. Evidence from placebo-controlled studies is inconsistent; most studies select a non-protein or noncaloric substance as a placebo. The proposed project will investigate the effects of a novel hydrolysed collagen preparation to initiate collagen synthesis and examine the effects of collagen hydrolysate on joint comfort and skin appearance. The study will compare the collagen hydrolysate preparation with hydrolysed milk protein and the typical placebo used in other studies. We will test the hypothesis that collagen hydrolysate positively affects the balance between collagen synthesis and degradation and improves pain scores and inflammation. The study will investigate the effects of consuming 15g of collagen hydrolysate or hydrolysed milk protein daily for 16 weeks on women over 50 years old with signs and symptoms of early osteoarthritis.



University of Auckland

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HVN Project / Programme Name


Data access requirements

For ethical reasons, no individualised data will be reported. Data will be presented as group mean and standard deviations.

Principal investigator organisation

Massey University

Collaborating researchers and affiliations

Primary investigators: Professor Jane Coad, School of Food and Advanced Technology, Massey University (Albany) A/P Matthew Barnes, School of Sport, Exercise and Nutrition, Massey University (Albany) Associate investigators: Dr Janet Weber (Massey University) Drew Gordon, Doctoral Student (Massey University)

Data description

Outcomes of the Study and associated data Primary Outcomes -change in osteoarthritis-related knee pain score (knee osteoarthritis outcome score (KOOS), visual analogue scale (VAS). Associated data: Changes in use of medication for knee pain, functional performance in Osteoarthritis Research Society International (OARSI)-endorsed activity domains, scores in activities of daily living and knee-related quality of life. Secondary Outcomes -Blood/urine biomarkers of collagen synthesis (serum N-propeptide of collagen IIA; PIIANP) & degradation (plasma cross-linked C-terminal telopeptide of type II collagen; CTX-II) -Blood biomarkers of inflammation (hsCRP and TNF-α) -Changes in skin thickness, hydration and elasticity Associated data: Blood/urine biomarkers of collagen synthesis and degradation, Blood biomarkers of inflammation, Skin thickness, elasticity, hydration Other Outcomes -Composite outcome of: Body composition (lean:fat ratio) assessed by whole-body Dual-energy X-ray absorptiometry (DXA) scan, air displacement plethysomography (BodPod) and bioelectrical impedance analysis (BIA); body mass index (BMI; height assessed by stadiometer, weight assessed by digital scales); waist:hip ratio (assessed by tape measure). -Lipid profile (serum total, high-density lipoprotein and low-density lipoprotein cholesterol; triglycerides) -Fasting blood glucose -Resting blood pressure -Tensile strength of hair -Composite assessment: tensile strength of fingernail clippings; nail thickness measured by a handheld electronic micrometer. Associated data: lean:fat ratio; serum total, high-density lipoprotein & low-density lipoprotein cholesterol; triglycerides; fasting glucose; resting blood pressure; tensile hair strength.

Principal investigator contact email

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