HVN1943 Metadata Record - Effects of collagen hydrolysate and milk protein on joint comfort and skin appearance in women over 50.

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Description: Previous research suggests consumption of hydrolysed collagen preparations may alleviate symptoms of osteoarthritis, the most common type of arthritis, usually affecting the knee, and with limited options for treatment. Inflammation and concomitant destruction of collagen in the connective tissue extracellular matrix are common mechanisms in osteoarthritis. Furthermore, most global collagen supplements are marketed as anti-ageing nutricosmetics to enhance skin appearance. Evidence from placebo-controlled studies is inconsistent; most studies select a non-protein or noncaloric substance as a placebo. The proposed project will investigate the effects of a novel hydrolysed collagen preparation to initiate collagen synthesis and examine the effects of collagen hydrolysate on joint comfort and skin appearance. The study will compare the collagen hydrolysate preparation with hydrolysed milk protein and the typical placebo used in other studies. We will test the hypothesis that collagen hydrolysate positively affects the balance between collagen synthesis and degradation and improves pain scores and inflammation. The study will investigate the effects of consuming 15g of collagen hydrolysate or hydrolysed milk protein daily for 16 weeks on women over 50 years old with signs and symptoms of early osteoarthritis.