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HVN1940 Metadata Record - The effect of a dairy based protein complex (IDP®) on stress-induced intestinal barrier dysfunction

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posted on 2024-01-16, 03:19 authored by Dulantha UlluwishewaDulantha Ulluwishewa

This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future.

Description: Disruption of the intestinal barrier and increased intestinal permeability may play a role in chronic intestinal conditions (such as celiac disease, inflammatory bowel disease, and irritable bowel syndrome), as well as pathological or inflammatory states such as obesity, diabetes and rheumatoid arthritis. In healthy individuals, barrier dysfunction can be caused by a number of stressors including endurance exercise, non-steroidal anti-inflammatory drugs, or dietary factors such as emulsifiers in foods. Increased permeability can lead to an inflammatory cascade that exacerbates the loss of barrier function and, if left unmanaged, can lead to poor digestive or systemic health conditions. However, certain dietary factors may improve barrier permeability by supporting digestive and immune health.

This project will investigate whether 14 days of consuming a patented complex of bioactive milk-derived proteins (Immune Defense Proteins (IDP)® ) can mitigate exercise-induced intestinal barrier dysfunction in 18 healthy adults, aged between 18 and 45 years. After 14 days of supplementation with either IDP or a placebo, participants will undertake 20 minutes of high-intensity running before ingesting a sugar solution. Urine will then be collected over 5 hours and analysed for markers of gut permeability. After a 14 day washout, participants will complete the same protocol using the opposite treatment (IDP or placebo).

We hypothesise that 14 days of consuming IDP will reduce the increase in intestinal permeability caused by exercise stress in healthy adults.

History

Publisher

University of Auckland

Temporal coverage: start

2021-01-01

HVN Project / Programme Name

HVN1940

Data access requirements

For ethical reasons, no individualised data will be reported. Data will be presented as group mean and standard deviations. Please contact the principal investigator if you wish to access the data.

Principal investigator organisation

AgResearch Ltd

Collaborating researchers and affiliations

Primary Investigator: Dr Dulantha Ulluwishewa, AgResearch Ltd, Te Ohu Rangahau Kai, Palmerston North Associate Investigators: A/Prof Matthew Barnes (Massey University) Dr Matthew Barnett (AgResearch) Dr Karl Fraser (AgResearch) Dr Daniel Bernstein (AgResearch)

Data description

Outcomes of the Study and associated data Primary Outcomes: -Gut barrier permeability, urine lactulose-to-rhamnose ratios (pre- and post-treatment) -Gut barrier permeability, urine lactulose-to-mannitol ratios (pre- and post-treatment) Associated data: Liquid Chromatography with tandem mass spectrometry (LC-MS-MS) data Secondary Outcome: -Gastrointestinal discomfort assessed immediately before, during, and immediately after high intensity exercise. Associated data: Gastrointestinal Symptom Rating Scale

Principal investigator contact email

dulantha.ulluwishewa@agresearch.co.nz

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