The University of Auckland
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HVN1924 Metadata Record - Acute effects of green kiwifruit on sleep quality and metabolites of sleep-wake cycles in healthy males

posted on 2024-01-16, 02:35 authored by Sharon Henare

This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future.

Description: Sleep is essential for the cellular repair of the body. One night of sleep disturbance can affect a person's ability to concentrate; increasing technical errors and their overall mood the following day. The neurohormone melatonin its precursor serotonin plays a central role in the regulation of sleep-wake. The levels of these neurohormones can be quantified in urine samples by measuring the metabolites of melatonin and serotonin as 6-sulfatoxymelatonin (aMT6s) and 5-hydroxyindoleacetic acid (5-HIAA), respectively. Diet has been shown to impact the levels of these hormones and may have an impact on sleep and mood (Garrido et al., 2010).

Kiwifruit is high in serotonin (Briguglio et al. 2018). The consumption of kiwifruit over one day is shown to increase levels of the 5-HIAA in urine samples. (Feldman & Lee, 1985). Furthermore, sleep quality is improved with the daily consumption of kiwifruit for four weeks (Lin et al. 2011). This project aims to determine the effect of an evening consumption of control, fresh or whole freeze-dried green kiwifruit on urinary metabolites of melatonin, serotonin, and b vitamins as well as subjective sleep quality, and mood in healthy young men.

A randomised controlled, crossover trial is planned. Participants will be given an evening standardised meal and the three intervention to consume with this water, fresh green kiwifruit or dried green kiwifruit powder to consume mixed with water. Upon waking the morning urine sample will be collected, and participants are to complete subjective sleep quality survey and mood survey. Samples and surveys are to be returned to the researcher. After approximately seven days, participants will be asked to consume the next intervention until all three have been consumed.



University of Auckland

Temporal coverage: start


HVN Project / Programme Name


Data access requirements

Individual participant data will not be available. Access to aggregate data may be possible, please contact the data champion for questions around access to the data.

Principal investigator organisation

Massey University

Collaborating researchers and affiliations

Principal Investigator: Dr Sharon Henare, School of Health Sciences, Massey University (Manawatu Campus) Associate Investigators: Alexander Kanon (Massey University), Doctoral candidate Caroline Giezenaar (Massey University) Professor Nicole Roy (University of Otago) Professor Warren McNabb (Riddet Institute)

Data description

Outcomes of the Study and associated data Primary Outcomes -Changes in 6-sulfatoxymelatonin in urine post intervention -Changes in 5-hydroxyindoleacetic acid in urine post intervention -Changes in subjective sleep quality and in objective sleep quality measurements (sleep onset latency, wake after sleep onset, total sleep time and sleep efficiency) following the intervention Associated data: Urine 6-sulfatoxymelatonin level, 5-hydroxyindoleacetic acid level, Stanford Sleepiness Scale and the Leeds Sleep Evaluation Questionnaire, wrist-worn actigraphy monitor data Secondary Outcomes -Changes in mood post intervention -Changes in urinary levels of water-soluble vitamins (Vitamin C, thiamine; riboflavin and its vitamer FMN; the B3 vitamers: nicotinic acid, nicotinamide and nicotinuric acid, and pantothenic acid; and the B6 vitamers pyridoxal, pyridoxamine, PLP, and 4-pyridoxic acid) post intervention Associated data: Profile of Mood States (POMS) survey, Urine water-soluble vitamins level

Principal investigator contact email