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HVN1917 Tahi Metadata Record - Tuhauora ka tahi: Effects of kawakawa containing beverage on the energy metabolism and physiology in healthy human volunteers

dataset
posted on 2023-12-13, 03:26 authored by Chris PookChris Pook

This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future.

Description: Kawakawa (Piper excelsum) a native NZ plant species, of cultural importance to Maori, and extensively used in rongoa Maori (traditional Maori healing). Despite considerable matauranga Maori of the therapeutic benefits of Kawakawa, research into the pharmacology of kawakawa is progressed little beyond identification the chemical profile. Kawakawa is reported to contain a number of pharmacologically active compounds demonstrated to influence pathways related to thermogenesis. We aim to explore the effect of adding kawakawa to a commercial beverage containing kiwi fruit powder and extracts of turmeric and ginger that has been formulated to stimulate postprandial thermogenesis. We hypothesise that consumption of the kawakawa-containing beverage will yield postprandial thermogenesis, measured as metabolic rate (energy expenditure) and respiratory quotient (relative substrate utilisation), proportional to the sum of that yielded by consumption of the beverage without kawakawa and that from an equivalent volume and strength of kawakawa tea.

History

Publisher

University of Auckland

Temporal coverage: start

2022-01-01

Temporal coverage: end

2023-01-01

HVN Project / Programme Name

HVN1917 Tahi

Data access requirements

All of the Individual participant data (including data dictionaries) collected during the trial will be available after de-identification, along with the study protocol. Data will be available beginning 3 months following the first publication of study results and ending 36 months following publication, to investigators who provide a methodologically sound proposal approved by the Study Steering Committee, for use to achieve the aims in the approved proposal. Proposals should be directed to the principal investigator (chris.pook@auckland.ac.nz). To gain access, requests will need to sign a data access agreement.

Principal investigator organisation

University of Auckland

Collaborating researchers and affiliations

Principal Investigator: Dr Chris Pook, University of Auckland, Auckland Co-Principal Investigators: Dr Farha Ramzan, Liggins Institute, University of Auckland, Auckland Dr Jennifer Miles-Chan, Human Nutrition Unit, University of Auckland, Auckland Co-Investigators: Professor Richard Mithen, Liggins Insititute, University of Auckland, Auckland Dr Meika Foster, Edible Research, University of Auckland, Auckland and Wakatū Incorporation Ramya Jayaprakash (PhD student)

Data description

Outcomes of the Study and associated data Primary outcomes - Metabolic rate (energy expenditure) - Respiratory quotient (relative substrate ultilisation) Associated data: Energy expenditure (EE), respiratory quotient (RQ) Secondary outcomes - Plasma metabolic profile - Urine metabolic profile - Plasma glucose - Plasma insulin - Cardiovascular profile (heart rate, blood pressure) - Body temperature - Visual analogue scale (VAS) scores of hunger, comfort, nausea, appetite and satiety - metabolic and inflammatory-related gene expression - body composition measured by dual Energy X-Ray Absorptiometry (iDXA) Associated data: plasma metabolites, urine metabolites, plasma glucose, plasma insulin, heart rate and blood pressure, body temperature, VAS composite score, metabolic and inflammatory-related gene expression (whole blood count, plasma and peripheral blood mononuclear cell (PBMCs) gene expression), body composition

Principal investigator contact email

chris.pook@auckland.ac.nz