This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future.
Description: There is growing concern about the health impacts of pollution, with increased industrialisation and population growth causing people to work and live in areas with poor air quality. Fruits and vegetables can contain various bioactives that have been reported to impact on airway inflammation, tissue remodelling and immune function. The overall aim of this study is to evaluate the efficacy of a Boysenberry and apple juice beverage consumption in reducing ozone-induced lung inflammation and maintaining normal lung function.
Publisher
University of AucklandTemporal coverage: start
2020-01-01HVN Project / Programme Name
HVN1911Data access requirements
To protect individual participants privacy, individual data will not be made availablePrincipal investigator organisation
Plant and Food ResearchCollaborating researchers and affiliations
Primary investigator:
Dr Dominic Lomiwes, Science Team Leader, Plant and Food Research, Palmerston North
Associate investigators:
Dr Odette Shaw (Plant and Food Research)
Dr Tony McGhie (Plant and Food Research)
Dr Greg Sawyer (Plant and Food Research)
Dr Brian Corley (University of Otago)Data description
Outcomes of the Study and associated data
Primary Outcomes:
-Exhaled nitric oxide (FeNO) levels pre and post ozone exposure pre and post ozone exposure
-Forced expiratory volume in 1 minute (FEV1) and forced vital capacity (FVC) to assess these clinically relevant parameters of participant’s lung function pre and post ozone exposure
Associated data: Exhaled nitric oxide (FeNO) level, Forced expiratory volume in 1 minute (FEV1), forced vital capacity (FVC)
Secondary Outcomes:
-Plasma cytokine concentrations pre and post ozone exposure
-White blood cell panel pre and post ozone exposure
-Oxidative potential (OPA) from plasma samples pre and post ozone exposure
-Plasma concentrations of anthocyanins (Bioavailability) pre and post ozone exposure
-Aryl-hydrocarbon receptor (AhR) expression to identify potential mechanism of action of BerriQi® boysenberry and apple beverage pre and post ozone exposure
-Malondialdehyde (MDA) concentration from plasma samples pre and post ozone exposure
-Protein carbonyls concentration from plasma samples pre and post ozone exposure
-Identification of bioactives using plasma samples
-Subjective lung health pre and post ozone exposure
Associated data: Plasma cytokine concentrations, White blood cells panel (flow cytometry data), Oxidative potential (OPA) from plasma, Plasma concentrations of anthocyanins, Aryl-hydrocarbon receptor (AhR) expression, Plasma malondialdehyde (MDA) concentration, Plasma protein carbonyls concentration, Identification of bioactives from plasma (untargeted metabolomics data), Lung health symptom scores (VAS), Chronic Respiratory QuestionnairePrincipal investigator contact email
dominic.lomiwes@plantandfood.co.nz
