HVN1904 MOVER Metadata Record - Musseling-up 2.0: Greenshell™ mussels for inflammation, metabolism and muscular skeletal function. Investigating the effect of long-term New Zealand green shell mussel powder consumption on promoting the recovery of muscle function following a bout of exercise-induced muscle damage to the quadriceps in untrained healthy males.
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Description: Prolonged and unaccustomed eccentric muscular work (like downhill walking) produces micro-structural damage to muscles resulting in inflammation and delayed soreness. Muscle damage from this exercise is associated with impaired muscle function (i.e. loss of muscle strength and mobility) and localised swelling/oedema. Although the mechanisms behind eccentric muscle damage are not precisely known, it is believed that along with initial mechanically induced disruption, secondary damage is caused by the inflammatory process and oxidative stress from inflammatory cells recruited to the site of injury. New Zealand green shell mussel (GSM) is rich in omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) which have been demonstrated to have anti-inflammatory properties. Green shell mussel contains additional bioactive components including glycosaminoglycans and other novel peptides and lipids that modulate inflammatory processes. Previous dietary intervention studies have reported the efficacy of New Zealand GSM to modulate key inflammatory factors leading to reduced soreness following exercise and improved lung function through reduced bronchoconstriction. These findings highlight the potential for New Zealand GSM supplementation to modulate exercise-induced inflammation and support recovery of muscle function following muscle damage. In this study, we seek to investigate the effect of long-term New Zealand GSM dietary supplementation in modulating inflammation and inflammatory pathways following exercise-induced muscle damage to the quadriceps. We will aim to examine whether any modulation in inflammation by GSM consumption leads to expedited recovery of musculo-skeletal performance following muscle damage.