The University of Auckland
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HVN1904 MINK Metadata Record - Musseling-up 2.0: Greenshell™ mussels for inflammation, metabolism and muscular skeletal function. The effect of green-shell mussel on joint health in elderly women.

posted on 2024-01-16, 02:02 authored by Matthew R Miller, Marlena Kruger

This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future.

Description: Osteoarthritis (OA) is the most common type of joint disease, contributing to progressive pain and disability in the elderly. In New Zealand, OA is affecting 10.2% of the adult population and the incidence escalating with age, and obesity causing the large health-related quality of life loss in NZ. The prevalence of OA is generally higher in women compared to men, as the incidence tend to consistently increase, particularly following menopause, likely due to losing the protective effect of estrogen on joint tissue. There is no cure for OA and the conventional treatment only used for symptom management. Oil extract from the Greenshell mussel (GSM), a native New Zealand shellfish, has been effective to reduce OA symptoms. A recent animal study showed flash-dried powder from whole GSM meat has preventive effects against the early-stage of metabolic-associated OA. In this study adding GSM powder into the diet of rats actively developing diet-induced OA reduced the cartilage degradation marker. Results from this preliminary study support the potential for an intervention study feeding human subjects with the whole meat GSM powder in order to attenuate the development of OA in a high-risk population. Therefore, this study aims to evaluate the effects of flash-dried whole meat GSM powder (3 g/day) or identical placebo for 12 weeks on cartilage and bone biomarkers, inflammation, body composition, health parameters, knee function and joint pain in healthy overweight/obese postmenopausal women.



University of Auckland

Temporal coverage: start


HVN Project / Programme Name


Data access requirements

Individual participant data collected during the trial will be made available, after de-identification

Principal investigator organisation

Cawthron Institute

Collaborating researchers and affiliations

Principal Investigators: Dr Matt Miller, Cawthorn Institute Professor Marlena Kruger, College of Health, Massey University (Manuwatu Campus) Associate Investigators: Dr Shaun Ogilvie (Cawthron Institute) Te Rerekohu Tuterangiwhiu (Cawthron Institute) Pamela von Hurst (Massey University) Dr Frances Wolber (Massey University) Dr Karl Fraser (AgResearch Ltd) Professor Jane Coad (Massey University) Dr Maryam Abshirini (Massey University)

Data description

Outcomes of the Study and associated data Primary Outcome: The changes in cartilage turnover markers; (CPII, COMP, CTX-II), bone resorption marker (CTX-I), measured at the end of the study in comparison with the week 6 and baseline values. Associated data: Urinary levels of CTx-II; Serum levels of CTX-I, CPII and COMP Secondary Outcomes: -The difference in the mean of inflammatory markers including hs-CRP and 13 cytokines namely IL-1β, interferon alpha-2 (IFN-α2), IFN-λ, TNF-α, monocyte chemoattractant protein-1 (MCP-1), IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-18, IL-23, and IL-33, as well as serum soluble transferrin receptor levels as an indicator of iron status measured at the end of the study in comparison with baseline values. -Changes in body composition including fat mass (FM), lean mass (LM), and fat percentage, joint pain, and knee function. Associated data: Serum hs-CRP, Blood cytokine panel, Serum soluble transferrin receptor levels, DXA data, NZPAQ-SF questionnaire and KOOS questionnaire

Principal investigator contact email