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Clonal dynamics limits detection of selection in tumour xenograft CRISPR/Cas9 screens

Version 2 2023-09-05, 04:15
Version 1 2023-05-31, 11:04
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posted on 2023-09-05, 04:15 authored by Tet Woo LeeTet Woo Lee, Francis HunterFrancis Hunter, Peter TsaiPeter Tsai, Cristin PrintCristin Print, William WilsonWilliam Wilson, Stephen JamiesonStephen Jamieson
<p dir="ltr">These repository contains data and analysis code for the manuscript of the same name. This version has been updated for the accepted version of the paper. Details of individual files:</p><p><br></p><ul><li>Lee_et_al__sample_details.tsv - details of samples present in counts file below; updated for accepted version of the paper</li><li>Lee_et_al__counts.tsv - gRNA counts from both pilot and larger screens described in paper</li><li>Lee_et_al__normalisation_factors.tsv - normalisation factors used in analysis of the above counts</li><li>invivo_gecko_lee_et_al_v2.zip - contains code and other files associated with the analyses of the above data; figures in the paper can be reproduced from these files; v2 is updated for the accepted version of the paper</li></ul><p><br></p><p dir="ltr">Note: This repository does not contain the data or code for the simulation studies described in the paper, which is available upon reasonable request to the authors.</p>

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