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Adult brain cortex spatial gene regulatory network

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This dataset consists of spatially constrained eQTLs. Briefly, all common single nucleotide polymorphisms (SNPs; MAF >0.05) present in adult brain cortex tissue were obtained from GTEx v8 and used to interrogate prepared Hi-C libraries. This allowed for the identification of SNP-gene pairs that are physically interacting. The identified SNP-gene pairs were then tested for eQTL effects by integrating eQTL data from GTEx v8. eQTLs with an adjusted p-value ≤0.05 were selected as being significant (Benjamini-Hochberg).

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University of Auckland