Nie, Tina Cooper, Garth Zhang, Shaoping Liu, Hong Vazhoor Amarsingh, Greeshma L44 mouse bodyweight, blood glucose and serum hormone data <p></p><p>Blood glucose, body weight and serum hormone characterisation of the L44 mouse, a model of obesity and type 2 diabetes, over 400 days. </p> <p> </p> <p>L44 mice overexpress a nonamyloidogenic and noncytotoxic variant of human amylin that contains three proline substitutions at residues 25, 28 and 29 ([<sup>25, 28, 29</sup>triprolyl]human amylin or tripro-hA). This allows for the study of the chronic effects of amylin overexpression. </p> <p> </p> <p>L44 mice were studied for a period of 400 days, with weekly blood glucose and body weight measurements. Three genotypes were examined; hemizygous (HEM), homozygous (HOM) and nontransgenic littermates (NON). Tissue and serum sample collection occurred at three time points:</p> <p><b>T1:</b> 100 days</p> <p><b>T2:</b> diabetes onset (3 consecutive weekly measurements of blood glucose > 11 mM)</p> <p><b>T3: </b>400 days</p> <p> </p> <p>Here, we provide weekly blood glucose and body weight measurements, and the circulating serum hormone levels of amylin, insulin and leptin at each time point. </p> <p> </p> <p>Abbreviations:</p> <p>BG = blood glucose (mM)</p> <p>BW = body weight (g)</p> <p> </p> <p>Sample IDs with a / are pooled serum samples from two individuals, e.g., T1 HEM 1/2 is a pooled sample with an equal volume of serum from T1 HEM 1 and T1 HEM 2.</p><p></p> body weight measurement;blood glucose data;Mouse Model Systems;diabetes;Obesity;amylin;Islet amyloid polypeptide;hormone concentrations;Animal Physiology - Systems;Endocrinology;Diseases 2019-06-18
    https://auckland.figshare.com/articles/dataset/L44_mouse_bodyweight_blood_glucose_and_serum_hormone_data/8285909
10.17608/k6.auckland.8285909.v1