10.17608/k6.auckland.8285909.v1
Tina Nie
Tina
Nie
Garth Cooper
Garth
Cooper
Shaoping Zhang
Shaoping
Zhang
Hong Liu
Hong
Liu
Greeshma Vazhoor Amarsingh
Greeshma
Vazhoor Amarsingh
L44 mouse bodyweight, blood glucose and serum hormone data
The University of Auckland
2019
body weight measurement
blood glucose data
Mouse Model Systems
diabetes
Obesity
amylin
Islet amyloid polypeptide
hormone concentrations
Animal Physiology - Systems
Endocrinology
Diseases
2019-06-18 22:35:05
Dataset
https://auckland.figshare.com/articles/dataset/L44_mouse_bodyweight_blood_glucose_and_serum_hormone_data/8285909
<p></p><p>Blood glucose, body weight and serum hormone characterisation
of the L44 mouse, a model of obesity and type 2 diabetes, over 400 days. </p>
<p> </p>
<p>L44 mice overexpress a nonamyloidogenic and noncytotoxic
variant of human amylin that contains three proline substitutions at residues 25,
28 and 29 ([<sup>25, 28, 29</sup>triprolyl]human amylin or
tripro-hA). This allows for the study of the chronic effects of amylin
overexpression. </p>
<p> </p>
<p>L44 mice were studied for a period of 400 days, with weekly
blood glucose and body weight measurements. Three genotypes were examined;
hemizygous (HEM), homozygous (HOM) and nontransgenic littermates (NON). Tissue
and serum sample collection occurred at three time points:</p>
<p><b>T1:</b> 100 days</p>
<p><b>T2:</b> diabetes onset (3 consecutive weekly measurements of
blood glucose > 11 mM)</p>
<p><b>T3: </b>400 days</p>
<p> </p>
<p>Here, we provide weekly blood glucose and body weight
measurements, and the circulating serum hormone levels of amylin, insulin and
leptin at each time point. </p>
<p> </p>
<p>Abbreviations:</p>
<p>BG = blood glucose (mM)</p>
<p>BW = body weight (g)</p>
<p> </p>
<p>Sample IDs with a / are pooled serum samples from two
individuals, e.g., T1 HEM 1/2 is a pooled sample with an equal volume of serum from
T1 HEM 1 and T1 HEM 2.</p><p></p>